Asimov identifies the 17th and 18th centuries as the period during which modern chemistry began to take shape. He discusses the work of key figures such as Robert Boyle, who laid the foundations for modern chemistry with his discovery of the relationship between pressure and volume of gases, and Antoine Lavoisier, who recognized the importance of quantitative measurements in chemistry. Asimov also highlights the contributions of other influential scientists, including Joseph Priestley, Henry Cavendish, and Carl Wilhelm Scheele, who discovered various elements and developed new chemical techniques.

Asimov begins his narrative in ancient times, discussing the early experiments with materials and the discovery of elements such as copper, bronze, and iron. He highlights the contributions of ancient civilizations, including the Egyptians, Greeks, and Chinese, who developed various chemical processes, such as metalworking, glassmaking, and dyeing. Asimov also discusses the philosophical and theoretical underpinnings of early chemistry, including the concept of the four elements (earth, air, fire, and water) and the idea of vitalism, which held that living organisms possessed a unique, non-material force.

The book's significance extends beyond the field of chemistry, as it provides insights into the development of scientific thought and the interplay between scientific and philosophical ideas. Asimov's work demonstrates that the development of science is a cumulative and iterative process, with scientists building upon the discoveries and ideas of their predecessors.

The latter part of Asimov's book focuses on the development of physical chemistry, which emerged as a distinct field in the late 19th and early 20th centuries. He discusses the work of scientists such as Svante Arrhenius, who developed the theory of electrolytic dissociation, and Gilbert Lewis, who introduced the concept of the covalent bond. Asimov also examines the development of quantum mechanics and its application to chemistry, which laid the foundations for modern physical chemistry.

Asimov's "A Short History of Chemistry" is significant not only for its comprehensive coverage of the field but also for its accessibility and engaging narrative style. The book has been widely praised for its ability to convey complex scientific concepts in a clear and concise manner. Asimov's work has also been recognized for its role in promoting a broader understanding of the history of science and the development of scientific thought.